DETAILED NOTES ON LDN-27219 CHEMICAL STRUCTURE

A single specifically fascinating compound is LDN-27219. Whilst most tTG inhibitors are designed to bind on the protein crosslinking active web-site, LDN-27219 as a substitute binds for the nucleotide binding pocket from the enzyme though it can be in its closed-condition conformation, and stabilizes that conformation to stop crosslinking activity.